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i have been on the emsam patch for 7 months & i have had better results on this med. than any other one. i tried the ssris' without success although cymbalta did work for a short while. i have tried anti-depressant for 3+ years and selegiline/emsam is the ONLY one that has given me any relief. i am on the 12mg patch and i have had no side effects..so far. the only thing i have had trouble with is getting them to "stick" for the full 24 hrs. an acceptable drawback for the help they have provided me even though a box doesn't last the full 30 days. yes, i know how to apply them. i have been diagnosed with major depressive disorder. i tried therapy w/ no med.'s for 2 years before giving med.'s a try. (read: i was desperate!) for over two years i tried different med.'s & combinations of Med.'s without success...my life full of despair, without hope, desperate, my soul enduring a slow agonizing, painful existance that i was trying to get enough courage to end. i planned to do it with a drug overdose of heroin or some narcotic i could obtain off the street. find a secluded place, start an i.v. drip containing the drug(i thought an ounce of heroin would do the job.) then lie down & go to sleep. fortunately, i followed the advice of my Dr. and kept trying. the effect of the emsam patch was nothing short of a miracle. the change i experienced over a few short weeks was incredible. i actually enjoy getting up early in the mornings and going to work. i have the ability to plan projects again. i can do things AND feel like completing them!! i like who i am today. i am a self-actualizing individual today. that was impossible before i started this patch. the diet restrictions have been no effort at all since i don't drink/drug or even like most of the restricted foods anyway. there is no way i can find the words to express the positive change in my life- how i feel...how i perceive the world now. i think it must be a God thing. it works for me!